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名稱	Recombinant Human GM-CSF
型號(hào)
更新時(shí)間	2023-09-24
特點(diǎn)	GM-CSF的造血生長(zhǎng)因子刺激中性粒細(xì)胞和巨噬細(xì)胞的發(fā)展和促進(jìn)早期的擴(kuò)散和發(fā)展紅色的巨核細(xì)胞和嗜酸性粒細(xì)胞的祖細(xì)胞。生產(chǎn)的內(nèi)皮細(xì)胞,單核細(xì)胞、成纖維細(xì)胞和淋巴細(xì)胞。gm - csf抑制中性粒細(xì)胞遷移和增強(qiáng)的功能活動(dòng)end-cells成熟。人類和小鼠分子具有種特異性,表現(xiàn)出沒(méi)有跨物種反應(yīng)性。}

詳細(xì)內(nèi)容

一.產(chǎn)品名稱：Recombinant Human GM-CSF

二.產(chǎn)地：Peprotech公司

三.貨號(hào)Catalog Number:AF-300-03

四.同義Synonyms:Granulocyte/Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-alpha

五.描述Description:

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. Manufactured using all non-animal reagents.

六.AA序列AA Sequence:

MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE

七.來(lái)源Source:E.coli

八.純度Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

九.活性Biological Activity:

The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁷ units/mg.

十.交叉性Cross Reactivity:Human, Mouse